by on Yesterday, 7:17 pm
The structural stability of these fibrillar assemblies is attributable to extensive interactions between the protein monomers, formed by spine hydrogen bonds between their β-strands. The misfolding of proteins can trigger the further misfolding and accumulation of different proteins into aggregates or oligomers. The increased levels of aggregated proteins within the cell leads to formation of amyloid-like structures which may cause degenerative disorders and cell demise. The amyloids are fibrill...
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